Listing of Clinical Trial Registries

May 28, 2015

The International Committee of Medical Journal Editors announced a policy in 2004 that as a condition of publication, clinical trials would be required to be listed in a public registry [1]. Subsequently, regulatory authorities around the world began to require the posting of clinical trial information and, in some cases, the submission of summary results to a publicly accessible registry. Likewise, some research funding agencies are now encouraging or requiring the registration and results reporting of the clinical trials they fund.

The World Health Organization Trial Registration Data Set directs that the following 20 elements be included in a clinical trial registry [2]:

Primary Registry and Trial Identifying Number
Date of Registration in Primary Registry
Secondary Identifying Numbers
Source(s) of Monetary or Material Support
Primary Sponsor
Secondary Sponsor(s)
Contact for Public Queries
Contact for Scientific Queries
Public Title
Scientific Title
Countries of Recruitment
Health Condition(s) or Problem(s) Studied
Intervention(s)
Key Inclusion and Exclusion Criteria
Study Type
Date of First Enrollment
Target Sample Size
Recruitment Status
Primary Outcome(s)
Key Secondary Outcomes

The 24 clinical trial registries that are national, regional, or international in scope are listed below, along with relevant laws and guidance documents [3]. Some, such as the WHO Search Portal and the Canadian Clinical Trial Database, are not technically classified as a “registry,” but are included in this Listing for the purpose of comprehensiveness. Registries that are recognized by the International Committee of Medical Journal Editors[4] are indicated with an asterisk: *

International:

Region / Country / Agency	Name of Registry	Guidelines
International Committee of Medical Journal Editors		Clinical Trial Registration: http://icmje.org/recommendations/browse/publishing-and-editorial-issues/clinical-trial-registration.html
World Health Organization – International Clinical Trials Registry Platform: http://www.who.int/ictrp/ en/	Search Portal: http://apps.who.int/trialsearch/	Resolution WHA 58.34 (2005): http://www.wpro.who.int/health_research/policy_documents/ministerial_summit_on_health_research_may2005.pdf?ua=1
World Medical Association		Declaration of Helsinki, Article 35 (2013): https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/

North America:

Region / Country / Agency	Name of Registry	Legislation	Guidelines
United States	ClinicalTrials.gov:* https://www.clinicaltrials.gov/ct2/home	Food and Drug Administration Modernization Act, Section 113 (1997): http://www.gpo.gov/fdsys/pkg/PLAW-105publ115/pdf/PLAW-105publ115.pdf#page=16 Food and Drug Administration Amendments Act, Section 801 (2007): http://www.gpo.gov/fdsys/pkg/PLAW-110publ85/pdf/PLAW-110publ85.pdf#page=82	National Library of Medicine: FAQs on ClinicalTrials.gov: https://www.clinicaltrials.gov/ct2/manage-recs/faq Food and Drug Administration: Guidance for Industry: Information Program on Clinical Trials for Serious or Life-Threatening Diseases and Conditions (2004): https://www.fda.gov/media/71927/download Department of Veterans Affairs: FAQ: http://www.research.va.gov/resources/ORD_Admin/clinical_trials/registration-faq.pdf
Canada	Health Canada Clinical Trial Database: http://www.hc-sc.gc.ca/dhp-mps/prodpharma/databasdonclin/index-eng.php		Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans, Article 11.3: http://www.pre.ethics.gc.ca/eng/documents/tcps2-2018-en-interactive-final.pdf

Region / Country / Agency

Name of Registry

Legislation

Guidelines

United States

ClinicalTrials.gov:*
https://www.clinicaltrials.gov/ct2/home

Food and Drug Administration Modernization Act, Section 113 (1997):
http://www.gpo.gov/fdsys/pkg/PLAW-105publ115/pdf/PLAW-105publ115.pdf#page=16
Food and Drug Administration Amendments Act, Section 801 (2007):
http://www.gpo.gov/fdsys/pkg/PLAW-110publ85/pdf/PLAW-110publ85.pdf#page=82

National Library of Medicine:

FAQs on ClinicalTrials.gov:
https://www.clinicaltrials.gov/ct2/manage-recs/faq

Food and Drug Administration:

Guidance for Industry: Information Program on Clinical Trials for Serious or Life-Threatening Diseases and Conditions (2004):
https://www.fda.gov/media/71927/download

Department of Veterans Affairs:

FAQ:
http://www.research.va.gov/resources/ORD_Admin/clinical_trials/registration-faq.pdf

Canada

Health Canada Clinical Trial Database:
http://www.hc-sc.gc.ca/dhp-mps/prodpharma/databasdonclin/index-eng.php

Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans, Article 11.3:
http://www.pre.ethics.gc.ca/eng/documents/tcps2-2018-en-interactive-final.pdf

Europe:

Region / Country / Agency	Name of Registry	Legislation	Guidelines
European Union	EU Clinical Trials Register:* https://www.clinicaltrialsregister.eu/	Clinical Trials Regulation No. 536/2014, Article 81: http://ec.europa.eu/health/files/eudralex/vol-1/reg_2014_536/reg_2014_536_en.pdf	FAQs: https://www.clinicaltrialsregister.eu/doc/EU_CTR_FAQ.pdf
Germany	German Clinical Trials Register:* https://www.drks.de/drks_web/		FAQs: https://www.drks.de/drks_web/navigate.do?navigationId=faq&messageDE=FAQ&messageEN=FAQ
Netherlands	Netherlands Trial Register (Dutch):* http://www.trialregister.nl/trialreg/index.asp
Switzerland	Swiss National Clinical Trials Portal: https://www.kofam.ch/en/snctp-portal/searching-for-a-clinical-trial/	Federal Act on Research Involving Human Beings, Articles 56, 64,65, and 67 (2011)	FAQs: http://www.kofam.ch/en/swiss-clinical-trials-portal/search-help-and-explanations.html
United Kingdom	ISRCTN:* http://www.isrctn.com/		ISRCTN: FAQs: http://www.isrctn.com/page/faqs Health Research Authority: Transparency, Registration, and Publication: http://www.hra.nhs.uk/resources/during-and-after-your-study/transparency-registration-and-publication/

Asia/Pacific/Middle East:

Region / Country / Agency	Name of Registry	Guidelines
Australia	Australian New Zealand Clinical Trials Registry:* http://www.anzctr.org.au/	1. National Statement on Ethical Conduct in Human Research, 3.3.12 (2014): http://www.nhmrc.gov.au/guidelines-publications/e72 2. FAQs: http://www.anzctr.org.au /Faq.aspx
China	Chinese Clinical Trial Registry:* http://www.chictr.org.cn/enIndex.aspx	FAQs: http://www.chictr.org.cn/questionen.aspx
India	Clinical Trials Registry – India:* http://ctri.nic.in/	Clinical Trials Registry – India: FAQs: http://ctri.nic.in/Clinicaltrials/faq.php Office of Drugs Controller General: Registration of Clinical Trial in ICMR Clinical Trial Registry: http://www.cdsco.nic.in/writereaddata/CTRegistration.doc
Iran	Iranian Registry of Clinical Trials:* http://www.irct.ir/	FAQs: http://www.irct.ir/page/help
Japan	Japan Primary Registries Network:* https://rctportal.niph.go.jp/	FAQs (Japanese): https://rctportal.niph.go.jp/how
Korea	Clinical Research Information Service:* https://cris.nih.go.kr/cris/en/use_guide/cris_introduce.jsp
New Zealand	Australian New Zealand Clinical Trials Registry: http://www.anzctr.org.au/	FAQs: http://www.anzctr.org.au/Faq.aspx
Philippines	Philippine Health Research Registry: http://registry.healthresearch.ph/	FAQs: http://registry.healthresearch.ph/index.php/component/healthregistry/?view=reports
Sri Lanka	Sri Lanka Clinical Trials Registry:* https://slctr.lk/	FAQs: http://slctr.lk/faq
Thailand	Thai Clinical Trials Registry:* http://www.clinicaltrials.in.th/	FAQs: http://www.clinicaltrials.in.th/index.php?meun=home&smenu=4&task=home&task1=openpage&task2=view&topid=4

Latin America/Caribbean:

Region / Country / Agency	Name of Registry	Guidelines
Brazil	Brazilian Clinical Trials Registry:* http://www.ensaiosclinicos.gov.br/	FAQs: http://www.ensaiosclinicos.gov.br/assistance/faq/
Cuba	Public Cuban Registry of Clinical Trials:* http://registroclinico.sld.cu/en/home
Peru	Peruvian Registry of Clinical Trials: https://www.ins.gob.pe/ensayosclinicos/

Africa:

Region / Country / Agency	Name of Registry	Guidelines
Pan Africa	Pan African Clinical Trials Registry:* https://pactr.samrc.ac.za/	FAQs: https://pactr.samrc.ac.za/FAQ.aspx
South Africa	South African National Clinical Trials Register: http://www.sanctr.gov.za/	FAQs: http://www.sanctr.gov.za/InvestigatorbrnbspInformation/FAQ/tabid/200/Default.aspx
Tanzania	Tanzania Clinical Trial Registry: http://www.tzctr.or.tz/	FAQs: http://www.tzctr.or.tz/faq.php

[1] http://www.icmje.org/news-and-editorials/clin_trial_sep2004.pdf

[2] http://www.who.int/iris/bitstream/10665/76705/1/9789241504294_eng.pdf?ua=1

[3] In addition, numerous disease-specific, device-specific, procedure-specific, and other registries are known to be in existence.

[4] http://www.icmje.org/