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Office for Human Research Protections

The Office for Human Research Protections (OHRP) provides leadership in the protection of the rights, welfare, and wellbeing of human subjects involved in research conducted or supported by the U.S. Department of Health and Human Services (HHS). OHRP is part of the Office of the Assistant Secretary for Health in the Office of the Secretary of HHS.

OHRP provides clarification and guidance, develops educational programs and materials, maintains regulatory oversight, and provides advice on ethical and regulatory issues in biomedical and behavioral research. OHRP also supports the Secretary's Advisory Committee on Human Research Protections (SACHRP), which advises the HHS Secretary on issues related to protecting human subjects in research.

About OHRP

Find out more about the Office for Human Research Protections.

Regulations, Policy & Guidance

Learn about federal regulations that protect human subjects in research and find policy and guidance materials related to the regulations.

Education & Outreach

Get information about OHRP educational events, programs, and materials.

Compliance & Reporting

Find out how OHRP exercises regulatory oversight and responds to reports of incidents in HHS-supported research.


Get the latest news and announcements from OHRP.

Register IRBs & Obtain FWAs

Learn how institutions can register IRBs and obtain FWAs.

SACHRP Committee

Find out more about the Secretary’s Advisory Committee on Human Research Protections.


Learn how OHRP promotes ethical conduct and regulatory compliance in HHS-supported research studies conducted outside the United States.