Multiple Chronic Conditions Research

The following is a list of selected publications and resources on the topic of multiple chronic conditions (MCC) associated with HHS.

Office of the Assistant Secretary for Health

• Arnett DK, Goodman RA, Halperin JL, Anderson JL, Parekh AK, Zoghbi WA. AHA/ACC/HHS strategies to enhance application of clinical practice guidelines in patients with cardiovascular disease and comorbid conditions  : from the American Heart Association, American College of Cardiology, and US Department of Health and Human Services. Circulation. 2014;130:1662–1667.
• Goodman RA, Parekh AK, Koh HK. Toward a more cogent approach to the challenges of multi-morbidity (editorial) . Ann Fam Med 2012;10:100-101.
• Goodman RA, Posner SF, Huang ES, Parekh AK, Koh HK. Defining and measuring chronic conditions: imperatives for research, policy, programs, and practice. Prev Chronic Dis 2013;10:120239.
• Goodman RA, Boyd C, Tinetti ME, Von Kohorn I, Parekh AK. IOM meeting on making clinical guidelines appropriate for patients with multiple chronic conditions . Ann Fam Med 2014;256-259.
• Koh HK, Parekh AK. Supporting people with multiple chronic conditions: a health priority. Huffington Post . December 5, 2013.
• Parekh AK, Barton MB. The challenge of multiple comorbidity for the U.S. health care system . JAMA 2010;303:1303-04.
• Parekh AK, Goodman RA, Gordon C, Koh HK. Managing multiple chronic conditions: a strategic framework for improving health outcomes and quality of life . Public Health Reports 2011;126:460-471.
• Parekh A.  A different normal: living with a chronic condition . WebMD. June 12, 2012. 
• Parekh AK. Help for People with Multiple Chronic Conditions . WebMD. September 11, 2012.
• Parekh A, Brennan N. New Web tool improves care for seniors with multiple chronic conditions . Health Affairs Blog. April 19, 2013. 
• Parekh A. Invited article on co-morbidities . enGINe June 2013.
• Parekh AK, Koh HK. Better data will lead to better care for those with multiple chronic conditions . Huffington Post.  July 10, 2013.
• Parekh AK, Goodman RA. The HHS Strategic Framework on Multiple Chronic Conditions: genesis and focus on research to benefit individuals . J Comorbidity 2013;3(2)22–29.
• Parekh AK, Kronick, R, Tavenner, M. Optimizing Health for Persons with Multiple Chronic Conditions . JAMA 2014; 312(12): 1199-1200
• U.S. Department of Health and Human Services. Multiple Chronic Conditions—A Strategic Framework: Optimum Health and Quality of Life for Individuals with Multiple Chronic Conditions. Washington, DC. December 2010.
• U.S. Department of Health and Human Services. Multiple Chronic Conditions Initiative. Private Sector Activities Focused on Improving the Health of Individuals with Multiple Chronic Conditions: INNOVATIVE PROFILES. Washington, DC. November 2012.

Office of the Assistant Secretary for Planning and Evaluation (ASPE) 

• LeRoy L, Wasserman M, White A. Understanding disparities in persons with multiple chronic conditions: research approaches and datasets . White paper prepared for ASPE, September 20, 2013.
• National Quality Forum. MCC Measurement Framework . 
• National Quality Forum endorsement of MCC measurement framework .
• Sorace J, Wong HH, Worrall C, Kelman J, Saneinejad S,  MaCurdy T. The complexity of disease combinations in the Medicare population . Population Health Management 2011; 14:161-166.

Administration on Community Living (ACL)

• Kleinman R, Foster L. Multiple chronic conditions among OAA Title III program participants. Administration on Aging. Research Brief Number 4.  July 2011. 

Agency for Healthcare Research and Quality (AHRQ) 

• Agency for Healthcare Research and Quality. The importance of investing in the care of people with multiple chronic conditions.  
• Agency for Healthcare Research and Quality’s website on MCC
• Agency for Healthcare Research and Quality's Multiple Chronic Conditions Research Network: Fact Sheet. May 2012. Agency for Healthcare Research and Quality, Rockville, MD.  
• Gerteis J, Izrael D, Deitz D, LeRoy L, Ricciardi R, Miller T, Basu J. Multiple Chronic Conditions Chartbook April 2014. Rockville, MD: Agency for Healthcare Research and Quality. (AHRQ Publications No, Q14-0038)
• Lugtenberg M, Burgers JS, Clancy C, Westert GP, Schneider EC. Current Guidelines Have Limited Applicability to Patients with Comorbid Conditions: A Systematic Analysis of Evidence-Based Guidelines. McCulloch P, ed. PLoS ONE 2011;6(10):e25987.
• Machlin S, Cohen JW, Beauregard K. Health care expenses for adults with chronic conditions, 2005. Statistical Brief #203 May 2008. Agency for Healthcare Research and Quality, Rockville, MD.
• Machlin SR, Soni A. Health care expenditures for adults with multiple treated chronic conditions: estimates from the Medical Expenditure Panel Survey, 2009. Prev Chronic Dis 2013;10:120172.
• Machlin S, Cohen S, Yu W. Health care access and expenditures among non-elderly adults with multiple chronic conditions: variations by insurance coverage status, 2007-08 (average annual). Statistical Brief #320. April 2011. Agency for Healthcare Research and Quality, Rockville, MD.   
• Medical Care Journal. Advancing the field: Results from the AHRQ Multiple Chronic Conditions Research Network, (Suppl 2) . March 2014;52:3.
  • Foreword - Parekh AK, Meyers, DS
  • Tinetti M, Basu, J. Research on Multiple Chronic Conditions: Where We Are and Where We Need to Go
  • Grembowski D, Schaefer, J, Johnson, KE, Fischer H, Moore S, Tai-Seale, M, Ricciardi R, Fraser J, Miller D, LeRoy L. A Conceptual Model of the Role of Complexity in the Care of Patients With Multiple Chronic Conditions
  • LeRoy L, Bayliss E, Domino M, Miller BF, Rust G, Gerteis J, Miller T. The Agency for Healthcare Research and Quality Multiple Chronic Conditions Research Network: Overview of Research Contributions and Future Priorities
• Multiple Chronic Conditions: A Day in the Life . November 2013. Agency for Healthcare Research and Quality, Rockville, MD.
• National Healthcare Disparities Report, 2013: Chapter 11. Priority Populations May 2014. Agency for Healthcare Research and Quality, Rockville, MD.   
• Steiner C, Friedman B. Utilization, cost and mortality for adult hospitalized patients with multiple chronic conditions in U.S. Acute Care Hospitals. Prev Chronic Dis 2013;10:120292. 
• Steiner CA, Barrett ML, Weiss AJ, Andrews RM. Trends and Projections in Hospital Stays for Adults With Multiple Chronic Conditions (MCC), 2003–2014. HCUP Statistical Brief #183. November 2014. Agency for Healthcare Research and Quality, Rockville, MD. 

Centers for Disease Control and Prevention (CDC) 

• Ashman J, Beresovsky V. Multiple chronic conditions among U.S. adults who visited the doctor: data from the National Ambulatory Medical Care Survey, 2009 Prev Chronic Dis 2013;10:120308.
• Barile JP, Thompson WW, Zack MM, Krahn GL, Horner-Johnson W, Bowen SE. Multiple Chronic Medical Conditions and Health-Related Quality of Life in Older Adults, 2004–2006 . Prev Chronic Dis 2013;10:120282.
• Crews JE, Jones GC, Kim JH. Double jeopardy: the effects of comorbid conditions among older people with vision loss. Journal of Visual Impairment and Blindness (Suppl) 2006;100:824-848.
• Centers for Disease Control and Prevention. Comorbidity in adults with epilepsy – United States, 2010. MMWR 2013;62:850-853.
• Freid VM, Bernstein AB, Bush MA. Multiple chronic conditions among adults aged 45 and over: Trends over the past 10 years. NCHS data brief, no 100. Hyattsville, MD: National Center for Health Statistics. 2012.
• Ford ES, Croft JB, Posner SF, Goodman RA, Giles WH. Co-occurrence of leading lifestyle-related co-occurring chronic conditions among adults in the United States, 2002—2009. Prev Chronic Dis 2013;10:120316.
• Fox MH, Reichard A. Disability, Health, and Multiple Chronic Conditions Among People Eligible for Both Medicare and Medicaid, 2005–2010. Prev Chronic Dis 2013;10:130064. 
• Freid VM, Bernstein AB, Bush MA. Multiple chronic conditions among adults age 45 and over: trends over the past 10 years. NCHS data brief, No. 100. Hyattsville, MD: National Center for Health Statistics. 2012. 
• Kramarow EA, Pastor PN.  The health of male veterans and nonveterans aged 25-64: United States 2007-2010. NCHS data brief, no 101. Hyattsville, MD: National Center for Health Statistics. 2012.
• Preventing Chronic Disease. PCD Collection: Multiple Chronic Conditions, (Suppl) April 25, 2013; 10.
  • Podcast
• Ward BW, Schiller JS. Prevalence of Multiple Chronic Conditions among US Adults: Estimates from the National Health Interview Survey, 2010. Prev Chronic Dis 2013;10:120203.
• Venkatesh A, Goodrich K, Conway P. Opportunities for Quality Measurement to Improve the Value of Care for Patients with Multiple Chronic Conditions[DHHS24] . Ann Intern Med 2014;161:S76-S80.

Centers for Medicare and Medicaid Services (CMS) 

• Barile JP, Thompson WW, Zack MM, Krahn GL, Horner-Johnson W, Bowen SE. Multiple Chronic Medical Conditions and Health-Related Quality of Life in Older Adults, 2004–2006. Prev Chronic Dis 2013;10:120282.
• Centers for Medicare and Medicaid Services. Chronic Conditions among Medicare Beneficiaries, Chartbook, 2011 Edition. Baltimore, MD. 2011.
• Centers for Medicare and Medicaid Services. Chronic Conditions among Medicare Beneficiaries, Chartbook, 2012 Edition. Baltimore, MD. 2012. 

• Chronic Conditions Data Warehouse. Interactive CMS Data: Chronic Conditions Dashboard.
• Centers for Medicare and Medicaid Services. Medicare Dashboard Advances ACA Goals for Chronic Conditions. 
• Centers for Medicare and Medicaid Services Geographic Data on Chronic Conditions and MCC.
  • Chronic Conditions data (state, county and hospital referral region levels)
  • Chronic Condition data dashboards (state, regional, county, hospital referral region levels)
  • Multiple Chronic Conditions data
  • Co-morbidity data

• Centers for Medicare and Medicaid Services. Report to Congress: The Centers for Medicare and Medicaid Services’ Evaluation of Community-based Wellness and Prevention Programs under Section 4204(b) of the Affordable Care Act. Baltimore, MD. 2013.
• Ling S, Reuben D, Tinetti ME. Patient Goal-Directed Care for Older Adults with Multiple and Complex Conditions. Medscape. August 29, 2014.
• Lochner KA, Cox CS. Prevalence of Multiple Chronic Conditions among Medicare Beneficiaries, United States, 2010. Prev Chronic Dis 2013;10:120137.
• Lochner K, Goodman RA, Posner SF, Parekh AK. Multiple Chronic Conditions among Medicare Beneficiaries: State-level Variations in Prevalence, Utilization, and Cost, 2011 . Medicare & Medicaid Research Review 2013;3:E1-19.

Food and Drug Administration 

• Digital Infuzion.  White Paper: U.S. Food and Drug Administration (FDA) Inventory of Clinical Trials Protocols and Clinical Study Data. August 31, 2011. 
• U. S. Department of Health and Human Services. Guidance on Conducting Clinical Trials. College Park, MD. 2013.

National Institutes for Health 

• Bayliss EA, Bonds, D, Boyd C, Davis M, Finke B et al. Understanding the Context of Health for Persons With Multiple Chronic Conditions: Moving from What Is the Matter to What Matters . Ann Fam Med 2014;260-269.
• Salive M. Multimorbidity in Older Adults . Epidemiol Rev 2013 Jan 31.
• Wallace RB, Salive ME. The Dimensions of Multiple Chronic Conditions: Where Do We Go From Here? A Commentary on the Special Collection of Preventing Chronic Disease . Prev Chronic Dis 2013;10:130104.
• Working Group on Health Outcomes for Older Persons with Multiple Chronic Conditions.  Universal health outcome measures for older persons with multiple chronic conditions .   J Am Geriatr Soc 2012;60:2333–2341.